Family: John Otis / Mary Jacob (F523)
m. 1653John Otis (1581-1657) 
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Margaret Elizabeth Streame (1598-1653)
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| Hannah Otis (1618-1676) |
| Richard Otis (1616-1689) |
| Nicholas Jacob (1597-1657)
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| Mary Gilman (1615-1681)
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| Joseph Jacobs (1646-1708) |
Deborah Loring Jacob (1643-1696)  |
| John Jacob (1630-1693) |
| Josiah Jacob (1642-1657) |
| Elizabeth Jacobs (1632-1725) |
| Josiah Jacob (1641-1642) |
| Hannah Jacob (1640-1720) |
| Sarah Jacobs (1641-1701) |
| John Otis (1621-1684)
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| Mary Jacob (1632-1684)
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| Mary Otis (1654-1733) |
| Hon John Otis (1657-1727) |
| Harrison Gray Otis ( -1848) |
| James Otis (1655-1690) |
| Elizabeth Otis (1656-1748) |
| Stephen Otis (1661-1733) |
| Judge Joseph Otis (1665-1754) |
| Hannah Otis (1659-1676) |
| Job Otis (1677-1758) |